Comparative Activity of Synthetic Antimicrobial Peptides Against Carbapenem-Resistant E. coli
Five novel cationic antimicrobial peptides (AMPs), inspired by natural motifs, were synthesized and evaluated against carbapenem-resistant clinical isolates of Escherichia coli. The AMPs varied in net charge (+4 to +8) and hydrophobicity. Minimal Inhibitory Concentration (MIC) assays revealed potent activity: AMP‑3 and AMP‑5 achieved MICs of 4 and 8 µg/mL, outperforming polymyxin B (MIC = […]
Photodynamic Inactivation of Multidrug‑Resistant Acinetobacter baumannii Using Chlorin‑e6 Nanocarriers
Photodynamic antimicrobial therapy (PACT) offers a promising alternative to traditional antibiotics. This work evaluates chlorin‑e6 (Ce6) encapsulated in PLGA nanoparticles against multidrug‑resistant Acinetobacter baumannii. Nanocarriers (~150 nm) exhibited ~80% Ce6 encapsulation efficiency. Under 660 nm LED light (50 J/cm²), PACT achieved ≥99.9% bacterial inactivation within 15 minutes in planktonic cultures. Biofilm viability was reduced by […]
“Evaluation of Zinc Oxide Nanoparticles Against Bacterial Biofilms”
Evaluation of Zinc Oxide Nanoparticles Against Bacterial Biofilms This study explores the synthesis and application of green‑synthesized zinc oxide nanoparticles (ZnO‑NPs) coated with polysaccharide stabilizers for eradication of mature bacterial biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus. Nanoparticles were produced using plant extract reduction, yielding a mean diameter of approximately 50 nm. In vitro […]